文献类型：期刊文献

英文题名：Direct Arylation of α-Amino C(sp3)-H Bonds by Convergent Paired Electrolysis

作者：Ma, Yueyue[1];Yao, Xiantong[1];Zhang, Lei[1];Ni, Pufan[1];Cheng, Ruihua[2];Ye, Jinxing[1]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Shanghai Key Lab New Drug Design,Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：58

期号：46

起止页码：16548

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20194407600659);WOS:【SCI-EXPANDED(收录号:WOS:000488575800001)，CCR-EXPANDED(收录号:WOS:000488575800001)】；

基金：This work was partially supported by National Natural Science Foundation of China (21272068, 21572056), Program for New Century Excellent Talents in University (NCET-13-0800), the Fundamental Research Funds for the Central Universities, 111 project (B07023), and the Open Project of State Key Laboratory of Chemical Engineering (SKL-ChE-17C01).

语种：英文

外文关键词：arylation; cross-coupling; C-H activation; electrocatalysis; tertiary amines

摘要：A metal-free convergent paired electrolysis strategy to synthesize benzylic amines through direct arylation of tertiary amines and benzonitrile derivatives at room temperature has been developed. This TEMPO-mediated electrocatalytic reaction makes full use of both anodic oxidation and cathodic reduction without metals or stoichiometric oxidants, thus showing great potential and advantages for practical synthesis. This convergent paired electrolysis method provides a straightforward and powerful means to activate C-H bonds and realize cross-coupling with cathodically generated species.