文献类型：期刊文献

英文题名：Friction-adaptive hydrogel coating for mechanical-immune synergy in ligament-to-bone integration

作者：Wang, Shuang[1,2];Chen, Tianwu[4];Li, Yong[5];Zhang, Lei[5];Wang, Jing[1,2];Liu, Changsheng[2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai, Peoples R China;[3]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai, Peoples R China;[4]Fudan Univ, Huashan Hosp, Sports Med Dept, Shanghai, Peoples R China;[5]Kunming Univ Sci & Technol, Inst Primate Translat Med, State Key Lab Primate Biomed Res, Kunming, Yunnan, Peoples R China

年份：2026

卷号：330

外文期刊名：BIOMATERIALS

收录：;EI(收录号：20261420400245);WOS:【SCI-EXPANDED(收录号:WOS:001683712500001)】；

基金：This study was supported by the Key Program of the National Natural Science Foundation of China (No. 32230059) , the Basic Science Center Program (No. T2288102) , the National Natural Science Foundation of China (100014717) (No. 32471406, No. 32101086, and No. 52202350, No. 82502978) , the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry (No. JKVD1211002) , and Key Research and Development Plan of Shandong Province (100014103) (2023CXPT103) .

语种：英文

外文关键词：PET artificial ligament; Foreign body reaction; Anterior cruciate ligament; Hydrogel coating

摘要：The long-term success of anterior cruciate ligament (ACL) reconstruction depends on the stable integration between artificial grafts and host bone. Despite their favorable mechanical strength, polyethylene terephthalate (PET) artificial ligaments often suffer from micromotion-induced fibrosis and persistent foreign body reactions (FBR), which together hinder osteointegration. Here, we develop a dual-network hydrogel coating with time-staged local immunomodulatory capability, enabling functional "mechano-immune" synergy at the graft-bone interface. Catechol-functionalized hyaluronic acid (HAMA-DOP) forms strong adhesive interactions with PET through it-it stacking, hydrogen bonding, and reversible covalent bonds. Subsequent oxidative crosslinking into a dense quinone-based secondary network enhances shear resistance and fatigue durability, while supporting self-healing. Pluronic F127 diacrylate (PF127-DA) introduces a thermoresponsive structure allowing the hydrogel to transition from injectable fluid at 4 degrees C to a stable gel at 37 degrees C, enabling localized and phase-specific release of celecoxib (CXB). This facilitates early suppression of inflammation and sustained promotion of regeneration. In vivo studies reveal a dose-dependent regulatory effect of CXB, where low-dose delivery promotes M2 macrophage polarization, H-type vessel formation, and bone bridging, while high doses impair immune homeostasis and osteointegration. This work establishes a robust, biologically responsive interface strategy, advancing the design of innovative coatings for enhanced outcomes in artificial ligament integration.