文献类型：期刊文献

英文题名：A concise asymmetric total synthesis for structure elucidation of 5,6-secoiridoid from Incarvillea argute

作者：Fu, Jian-Jun[1];Liu, Zhi-Qian[2];Jin, Hui-Zi[3];Zhang, Shou-De[1];Sun, Qing-Yan[4];Zhang, Wei-Dong[1,2,4]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China;[4]Shanghai Inst Pharmaceut Ind, Shanghai 200040, Peoples R China

年份：2016

卷号：6

期号：76

起止页码：72458

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20163202691121);WOS:【SCI-EXPANDED(收录号:WOS:000381513300077)】；

基金：The work was supported by Professor of Chang Jiang Scholars Program, National Natural Science Foundation of China (81520108030, 81573318, 81373301, 1302658), Shanghai Leading Academic Discipline Project (B906), Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), and the Fundamental Research Funds for the Central Universities of China.

语种：英文

外文关键词：Synthesis (chemical) - Cancer cells

摘要：A phytochemical investigation of the roots of Incarvillea arguta led to the isolation of secoarguterin (1), which is the first example of 5,6-secoiridoid. Its structure and absolute configuration was elucidated by extensive spectral analysis and total synthesis. Compound 1 showedmoderate inhibition against human colon cancer cells HCT116 with an IC50 value of 28.72 mu M.