文献类型：期刊文献

英文题名：High Frequency and Addressable Impedance Measurement System for On-Site Droplet Analysis in Digital Microfluidics

作者：Zeng, Jin[1];Xu, Hang[1];Song, Ze-Rui[1];Zhou, Jia-Le[1];Jiang, Guo-Jun[1];Yan, Bing-Yong[1];Gu, Zhen[1];Wang, Hui-Feng[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Smart Mfg Energy Chem Proc, Minist Educ, Shanghai 200237, Peoples R China

年份：2024

卷号：13

期号：14

外文期刊名：ELECTRONICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001277230000001)】；

基金：This research was funded by the National Key R&D Program of China (2021YFC2101101)and the National Natural Science Foundation of China (No. 62103148).

语种：英文

外文关键词：digital microfluidics; impedance measurement; high frequency; addressable; online detection

摘要：Digital microfluidics is a novel technique for manipulating discrete droplets with the advantages of programmability, small device size, low cost, and easy integration. The development of droplet sensing methods advances the automation control of digital microfluidics. Impedance measurement emerges as a promising technique for droplet localization and characterization due to its non-invasive nature, high sensitivity, simplicity, and cost-effectiveness. However, traditional impedance measurement approaches in digital microfluidics based on the high-voltage actuating signal are limited in sensing accuracy in practical applications. In this paper, we propose a novel droplet impedance sensing system for digital microfluidics by introducing a low-voltage and addressable measurement circuit, which enables impedance measurement over a wide frequency range. The proposed measurement system has also been used for detecting the droplet composition, size, and position in a digital microfluidic chip. The improved impedance sensing method can also promote the applications of the digital microfluidic, which requires high accuracy, real-time, and contactless sensing with automatic sample pretreatment.