文献类型：专利

英文题名：New N-(4-substituted phenethyl)amide compound useful in preparing medicine for treating malaria caused by Plasmodium falciparum

作者：ZHU J;HUANG J;CHEN W;YAO X;LING D;WANG M;JIANG H;LI J

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY

申请号：CN106938997-A

申请日：2017-01-17

公开日：2017-07-11

语种：英文

收录：DERWENT

摘要：NOVELTY - N-(4-substituted phenethyl)amide compound (I) is new. USE - (I) is useful in preparing medicine for treating malaria caused by Plasmodium falciparum (claimed). ADVANTAGE - (I) has excellent inhibiting effect on wild and drug-resistant Plasmodium falciparum. DETAILED DESCRIPTION - N-(4-substituted phenethyl)amide compound of formula (I) is new. R1 = (2,4-diaminopyrimidine-5-yl-methyl)amino or (2,4-diaminopyrimidine-5-yl-methylen)amino; R2 = 1-4C alkyl ( optionally substituted with phenyl), 4-13C cycloalkyl, heterocyclic or aryl ring, or substituted 4-13C cycloalkyl, heterocyclic group or aromatic ring group; heteroatom = nitrogen, oxygen or sulfur; substituted 4-13C cycloalkyl = 1-4C alkyl, 1-4C alkoxy, halo, hydroxy, ketone carbonyl or dimethoxymethane of formula (II); and n = 1 or 2.