文献类型：期刊文献

英文题名：Eutectic Solvents Based on Matrine and Fatty Acids as Solubility and Stability Enhancers of Curcumin

作者：Liu, Zhuoni[1];Zhang, Xianshuo[2];Wang, Xiaoyong[1];Yin, Tianxiang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Anyang Normal Univ, Sch Chem & Chem Engn, Anyang 455000, Henan, Peoples R China

年份：2025

卷号：129

期号：3

起止页码：990

外文期刊名：JOURNAL OF PHYSICAL CHEMISTRY B

收录：;EI(收录号：20250217662789);WOS:【SCI-EXPANDED(收录号:WOS:001393238300001)】；

基金：This work was supported by the National Natural Science Foundation of China (projects 21773063 and 22273022).

语种：英文

外文关键词：Fatty acid methyl ester - Solubility

摘要：Eutectic solvents (ESs) have shown great efficiency on increasing the solubility, stability, and bioactivity of active pharmaceutical ingredients (APIs) in recent research studies. Curcumin is an important API driven from natural plants, which displayed a series of biofunctions like antibacterials, anti-inflammatory, and anticancer activities etc. However, its poor water solubility and stability hindered its further clinic application. Herein, a series of novel ESs based on matrine and fatty acids (i.e., octanoic acid, decanoic acid, and lauric acid) were developed. The phase behavior and cytotoxicity of these ESs were investigated. Moreover, the prepared ESs displayed excellent ability on enhancing the solubility of curcumin with the highest solubility being 28 mg/mL at 298 K, which was nearly 50000-fold than that in water. The curcumin showed high stability in ESs, where only 10% of curcumin decomposed under light irradiation for 6 h. Furthermore, biofilms based on these ES solutions of curcumin have been prepared and displayed high antioxidant and antibacterial activities. To summarize, the prepared eutectic systems provide a new strategy for further application of curcumin.