文献类型：期刊文献

英文题名：Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle

作者：Chen, Xu-bing[2];Zhuang, Jing-jing[2];Liu, Jun-hua[2];Lei, Min[1];Ma, Lei[2];Chen, Jing[1];Shen, Xu[1,2];Hu, Li-hong[1,2]

机构：[1]Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2011

卷号：19

期号：19

起止页码：5776

外文期刊名：BIOORGANIC & MEDICINAL CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000295426400005)】；

基金：This work was supported by the National Natural Science Foundation of China (Grants 90713046, 30925040), and CAS Foundation (Grant KSCX2-YW-R-179).

语种：英文

外文关键词：Siraitia grosvenorii Swingle; Cucurbitane triterpenoids; AMPK; HepG2 cell; Anti-diabetic effect

摘要：AMP-activated kinase (AMPK) as a key controller in the regulation of whole-body energy homeostasis, plays an important role in protecting the body from metabolic diseases. Recently, improved glucose, lipid utility and increased insulin sensitivity were observed on several diabetic rodent models treated with crude mogrosides isolated from the fruit of Siraitia grosvenorii Swingle, but the precise active compounds responsible for the anti-diabetic activity of this plant have not been clearly identified. In our current work, acid hydrolysis of crude mogrosides provided five new cucurbitane triterpenoids (1-4, 8), along with three known ones (5-7). The main aglycone mogrol (7) and compounds 4 and 8 were found to be potent AMPK activators in the HepG2 cell line. This result suggested AMPK activation by the mogroside aglycones 7 and 8 was proved to contribute at least partially to the anti-hyperglycemic and anti-lipidemic properties in vivo of S. grosvenorii. (C) 2011 Elsevier Ltd. All rights reserved.