文献类型：期刊文献

英文题名：Microneedle Assisted Melittin-Chondroitin Sulfate Administration for the Transdermal Therapy of Rheumatoid Arthritis

作者：Jin, Lili[1,2,3];Wang, Zhenhui[2,3];Peng, Cheng[4];He, Miao[2];Wang, Feng[4];He, Hongyan[1,2,3];Liu, Changsheng[1,2]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[4]Shanghai Normal Univ, Shanghai Frontiers Sci Ctr Biomimet Catalysis, Shanghai Key Lab Rare Earth Funct Mat, Educ Minist Key Lab Resource Chem,Joint Int Res La, Shanghai 200234, Peoples R China

年份：2025

卷号：14

期号：9

外文期刊名：ADVANCED HEALTHCARE MATERIALS

收录：;EI(收录号：20250917952563);WOS:【SCI-EXPANDED(收录号:WOS:001425680500001)】；

基金：This work was financially supported by National Key Research and Development Plan Strategic International Science and Technology Innovation Cooperation Key Projects (SQ2018YF020328), the National Natural Science Foundation of China for Innovative Research Groups (Grant No. 51621002), the Fundamental Research Funds for the Central Universities, State Administration of Foreign Experts Affairs P.R. China (Grant No. B14018).

语种：英文

外文关键词：chondroitin sulphate; melittin; microneedles; rheumatoid arthritis; surface-enhanced Raman scattering

摘要：Rheumatoid arthritis (RA), a persistent and debilitating chronic disease characterize by joint damage and deformity, significantly impairs the life quality of patients and presents challenges for conventional drug administration due to organ damage and unsatisfactory therapeutic outcomes. To address these challenges, this study introduces an innovative hydrogel cryo-microneedle patch (CMNP)-mediated local administration system, primarily composed of chondroitin sulfate (CS), to deliver the potent anti-inflammatory drug melittin (MEL). This innovative approach not only circumvents organ impairment but also enhances patient compliance. The acute toxicity of MEL is effectively mitigated by electrostatic binding with CS molecules, forming MC complexes that induce apoptosis in fibroblast-like synoviocytes (FLS). The MC-loaded CMNPs (MC@CCMNPs) exhibit remarkable therapeutic capacity with a notably meliorated joint damage and suppressed arthritis severity in the RA rat model. Therefore, MC@CCMNPs emerge as a promising anti-inflammatory and safe therapy for RA treatment, as well as for other inflammation related chronic diseases.