文献类型：期刊文献

英文题名：Neural Energy Supply-Consumption Properties Based on Hodgkin-Huxley Model

作者：Wang, Yihong[1];Wang, Rubin[1];Xu, Xuying[1]

机构：[1]East China Univ Sci & Technol, Inst Cognit Neurodynam, 130 Meilong Rd, Shanghai, Peoples R China

年份：2017

卷号：2017

外文期刊名：NEURAL PLASTICITY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000395192200001)】；

基金：This work is supported by the National Natural Science Foundation of China (nos. 11232005, 11472104) and The Ministry of Education Doctoral Foundation (no. 20120074110020).

语种：英文

摘要：Electrical activity is the foundation of the neural system. Coding theories that describe neural electrical activity by the roles of action potential timing or frequency have been thoroughly studied. However, an alternative method to study coding questions is the energy method, which is more global and economical. In this study, we clearly defined and calculated neural energy supply and consumption based on the Hodgkin-Huxley model, during firing action potentials and subthreshold activities using ioncounting and power-integralmodel. Furthermore, we analyzed energy properties of each ion channel and found that, under the two circumstances, power synchronization of ion channels and energy utilization ratio have significant differences. This is particularly true of the energy utilization ratio, which can rise to above 100% during subthreshold activity, revealing an overdraft property of energy use. These findings demonstrate the distinct status of the energy properties during neuronal firings and subthreshold activities. Meanwhile, after introducing a synapse energy model, this research can be generalized to energy calculation of a neural network. This is potentially important for understanding the relationship between dynamical network activities and cognitive behaviors.