文献类型：期刊文献

英文题名：Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy

作者：Bai, Long[1,2,3,6];Liu, Yanpeng[1,3,6];Zhang, Xiaohui[1,3,6];Chen, Peiru[5];Hang, Ruiqiang[4];Xiao, Yin[7,8];Wang, Jing[1];Liu, Changsheng[1,3,6]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Univ, Inst Translat Med, Shanghai 200444, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]Taiyuan Univ Technol, Coll Mat Sci & Engn, Shanxi Key Lab Biomed Met Mat, Taiyuan 030024, Peoples R China;[5]Beijing Proteome Res Ctr, Inst Lifeom, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing 102206, Peoples R China;[6]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China;[7]Griffith Univ, Sch Med & Dent, Gold Coast, Australia;[8]Queensland Univ Technol, Australia China Ctr Tissue Engn & Regenerat Med, Brisbane, Australia

年份：2023

卷号：297

外文期刊名：BIOMATERIALS

收录：;EI(收录号：20231513881396);WOS:【SCI-EXPANDED(收录号:WOS:000983285500001)】；

基金：This work was jointly supported by the Basic Science Center Program (No. T2288102) , the Key Program of the National Natural Science Foundation of China (No. 32230059) , the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002) , the Foundation of Frontiers Science Center for Materiobiology and Dy- namic Chemistry (No. JKVD1211002) , the National Natural Science Foundation of China (No. 31870953, 81901898) , the Central Leading Science and Technology Development Foundation of Shanxi Province (No. YDZJSX2021A019) , the Natural Science Foundation of Shanxi Province (No. 20210302123100) and the China Postdoctoral Science Foundation (No. 2019M661404, No. 2020T130192) .

语种：英文

外文关键词：Icariin; Macrophage; Inflammaging; Autophagy; Osteoporosis

摘要：The pace of bone formation slows down with aging, which leads to the development of osteoporosis. In addition to senescent bone marrow mesenchymal stem cells (S-BMSCs), senescent macrophages (S-M0s) present in the bone marrow produce numerous inflammatory cytokines that contribute to the inflammaged microenvironment and are involved in the development of osteoporosis. Although autophagy activation has shown a significant anti-aging effect, its influence on inflammaging and its role in osteoporosis treatment remain unclear. Traditional Chinese herbal medicine contains bioactive components that exhibit remarkable advantages in bone regeneration. We have demonstrated that icariin (ICA), a bioactive component of traditional Chinese herbal medicine, activates autophagy, exerts a significant anti-inflammaging effect on S-M0s, and rejuvenates osteogenesis of SBMSCs, thereby alleviating bone loss in osteoporotic mice. The transcriptomic analysis further reveals that the TNF-alpha signaling pathway, which is significantly associated with the level of autophagy, regulates this effect. Moreover, the expression of senescence-associated secretory phenotype (SASP) is significantly reduced after ICA treatment. In summary, our findings suggest that bioactive components/materials targeting autophagy can effectively modulate the inflammaging of S-M0s, offering an innovative treatment strategy for osteoporosis remission and various age-related comorbidities.