文献类型：期刊文献

英文题名：Photodynamic Therapy of Oligoethylene Glycol-Dendronized Reduction-Sensitive Porphyrins

作者：Ju, Mingjie[1];Pang, Jundi[2];Xu, Ligong[1]

机构：[1]East China Univ Sci & Technol, Sch Sports Sci & Engn, Shanghai 200237, Peoples R China;[2]Kunming Med Univ, Kunming 650500, Yunnan, Peoples R China

年份：2017

卷号：35

期号：9

起止页码：1445

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000411723600014)】；

语种：英文

外文关键词：graphene oxide; photodynamic therapy; porphyrindisulfide

摘要：Graphene oxide (GO) and its functionalized derivatives have attracted increasing attention in medical treatment. Herein, a reduction sensitive PEI-GO-SS-TPP was synthesized for photodynamic therapy. More than 80% porphyrin release was observed in the presence of 10mmol center dot L-1 DTT in one day. The confocal laser scanning microscopy confirmed that the cell uptake efficiency of PEI-GO-SS-TPP was remarkably enhanced as compared to free porphyrin which was significantly dependent on incubation time. For photodynamic therapy, GSH-OEt could effectively increase the photodynamic therapy efficiency of PEI-GO-SS-TPP. Compared with free porphyrin, the toxicity from PEI-GO-SS-TPP is much higher with a low IC50 (2.1 mu g/mL) value. All results indicate that the PEI-GO-SS-TPP PSs are promising for photodynamic therapy.