文献类型：期刊文献

英文题名：Photocontrollable release and enhancement of photodynamic therapy based on host-guest supramolecular amphiphiles

作者：Xu, Lei[1];Zhang, Wenyan[1];Cai, Haibo[1];Liu, Feng[1];Wang, Yong[2];Gao, Yun[1];Zhang, Weian[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Nanjing Tech Univ, Coll Chem & Chem Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Peoples R China

年份：2015

卷号：3

期号：37

起止页码：7417

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20153801293257);WOS:【SCI-EXPANDED(收录号:WOS:000361554100012)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 51173044), the Science and Technology Commission of Shanghai Municipality (No. 15JC1401402), Shanghai Pujiang Program (No. 14PJ1402600), Research Innovation Program of SMEC (No. 14ZZ065), and the State Key Laboratory of Materials-Oriented Chemical Engineering (No. KL14-03). W. Z. also acknowledges the support from the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Amphiphiles - Irradiation - Micelles - Cell culture - Efficiency - Supramolecular chemistry - Photosensitizers

摘要：A light-controlled porphyrinic photosensitizer release system was developed based on host-guest TPP-Azo/PEG-beta-CD supramolecular amphiphiles, which could significantly enhance the efficiency of photodynamic therapy. TPP-Azo was prepared via esterification between TPP and Azo derivatives, and further used to construct supramolecular amphiphiles with PEG-beta-CD. TEM images showed that TPP-Azo/PEG-beta-CD amphiphiles can self-assemble into spherical micelles, and then disaggregate under irradiation with 365 nm UV light. The phototoxicity and bio-distribution of TPP-Azo/PEG-b-CD micelles against the MCF-7 cell line were also evaluated by MTT assay, flow cytometry and confocal scanning laser microscopy, respectively. According to MTT assay, the IC50 of the spherical micelle was 31.2 mu g mL(-1), but it became 20.6 mu g mL(-1) upon pre-irradiation with 365 nm UV light. This shows for the first time that UV light can well stimulate the release of porphyrin photosensitizers and improve the photodynamic therapy efficiency based on the system of host-guest supramolecular amphiphiles.