文献类型：期刊文献

英文题名：Genotoxicity of Tri- and Hexavalent Chromium Compounds In Vivo and Their Modes of Action on DNA Damage In Vitro

作者：Fang, Zhijia[1];Zhao, Min[1];Zhen, Hong[2];Chen, Lifeng[2];Shi, Ping[2];Huang, Zhiwei[1]

机构：[1]Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2014

卷号：9

期号：8

外文期刊名：PLOS ONE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000341105100014)】；

基金：This work was sponsored by grants from the National Natural Science Foundation of China (31100549, PS), Scientific Research Foundation for the Returned Overseas Chinese Scholars(PS, ZH), State Education Ministry and Fundamental Research Funds for the Central Universities (2232014A3-03, ZH and 222201313010, PS), the National Special Fund for State Key Laboratory of Bioreactor Engineering (2060204, PS). The funders had a role in study design, data collection and analysis, decision to publish, and preparation of the manuscript.

语种：英文

摘要：Chromium occurs mostly in tri- and hexavalent states in the environment. Hexavalent chromium [Cr(VI)] compounds are extensively used in diverse industries, and trivalent chromium [Cr(III)] salts are used as micronutrients and dietary supplements. In the present work, we report that they both induce genetic mutations in yeast cells. They both also cause DNA damage in both yeast and Jurkat cells and the effect of Cr(III) is greater than that of Cr(VI). We further show that Cr(III) and Cr(VI) cause DNA damage through different mechanisms. Cr(VI) intercalates DNA and Cr(III) interferes base pair stacking. Based on our results, we conclude that Cr(III) can directly cause genotoxicity in vivo.