文献类型：期刊文献

英文题名：Novel total syntheses of oxoaporphine alkaloids enabled by mild Cu-catalyzed tandem oxidation/aromatization of 1-Bn-DHIQs

作者：Zheng, Bo;Qu, Hui-Ya;Meng, Tian-Zhuo;Lu, Xia;Zheng, Jie;He, Yun-Gang;Fan, Qi-Qi;Shi, Xiao-Xin[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, 130 Mei Long Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Engn, 130 Mei Long Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：8

期号：51

起止页码：28997

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20183505744270);WOS:【SCI-EXPANDED(收录号:WOS:000444700100018)】；

基金：We are grateful to the National Natural Science Foundation of China (No. 20972048, 20172015) for the financial support of this work.

语种：英文

外文关键词：Synthesis (chemical) - Catalysis

摘要：Novel total syntheses of oxoaporphine alkaloids such as liriodenine, dicentrinone, cassameridine, lysicamine, oxoglaucine and O-methylmoschatoline were developed. The key step of these total syntheses is Cu-catalyzed conversion of 1-benzyl-3,4-dihydro-isoquinolines (1-Bn-DHIQs) to 1-benzoyl-isoquinolines (1-Bz-IQs) via tandem oxidation/aromatization. This novel Cu-catalyzed conversion has been studied in detail, and was successfully used for constructing the 1-Bz-IQ core.