文献类型：期刊文献

中文题名：Synthesis of Hirtellanine B, an Isoflavonoid with Potent Antiproliferative Effects in Cancer Cells

英文题名：Synthesis of Hirtellanine B, an Isoflavonoid with Potent Antiproliferative Effects in Cancer Cells

作者：Zheng Shuyan[1];Fu Runzhong[2];Shen Zhengwu[1,3]

机构：[1]Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China;[2]E China Univ Sci & Technol, Dept Appl Chem, Shanghai 20000, Peoples R China;[3]Basilea Pharmaceut China Ltd, Haimen 226100, Jiangsu, Peoples R China

年份：2012

卷号：30

期号：7

起止页码：1405

中文期刊名：Chinese Journal of Chemistry

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000306562300006)，CCR-EXPANDED(收录号:WOS:000306562300006)】；CSCD:【CSCD2011_2012】；

基金：The authors would like to thank Basilea Pharmaceutica China for supporting these studies. The authors also appreciate the help provided by Prof. Peilan He from Shanghai Institute of Material Medica, Chinese Academy of Sciences, Shanghai, China.

语种：英文

中文关键词：hirtellanine B;synthesis;antiproliferation;G2/M arrest;cancer cell

外文关键词：hirtellanine B; synthesis; antiproliferation; G2; M arrest; cancer cell

摘要：We reported the first total synthesis of hirtellanine B, using oxidative coupling for the key reactions, which resulted in a high yield. The antiproliferative activities of hirtellanine B against Jurkat cells, Raji cells and K562 cells were also investigated. It was found that hirtellanine B could induce G2/M arrest and apoptosis in human lymphoid/leukemia tumor cells.
We reported the first total synthesis of hirtellanine B, using oxidative coupling for the key reactions, which resulted in a high yield. The antiproliferative activity of hirtellanine B against Jurkat cells, Raji cells and K562 cells were also investigated. It was found that hirtellanine B could induce G2/M arrest and apoptosis in human lymphoid/leukemia tumor cells.