文献类型：期刊文献

英文题名：Reversible Adhesive Hydrogel Balancing Conflicting Needs of Strong Adhesion and Painless Removal for Diabetic Joint Wound Healing

作者：Song, Pengyu[1];Sun, Qingmei[1];Liang, Xue[1];Li, Jianrui[1];Shi, Junqiu[1];Zhu, Yunqing[1,2];Du, Jianzhong[2,3,4,5]

机构：[1]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai 201804, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]Tongji Univ, Shanghai Peoples Hosp 4, Sch Med, Clin Res Ctr Anesthesiol & Perioperat Med,Translat, Shanghai 200434, Peoples R China;[4]Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Orthopaed, Shanghai 200072, Peoples R China;[5]Tongji Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Civil Engn Mat, Shanghai 201804, Peoples R China

年份：2025

卷号：19

期号：27

起止页码：25466

外文期刊名：ACS NANO

收录：;EI(收录号：20252718718920);WOS:【SCI-EXPANDED(收录号:WOS:001521606900001)】；

基金：This work was supported by the National Natural Science Foundation of China (22335005 and 22175131), the National Key R&D Program of China (2022YFC2402900), the Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28), the Fundamental Research Funds for the Central Universities, the Interdisciplinary Collaborative Research Project of Tongji University (2023-2-YB-03), and the Tongcheng Youth Research and Development Fund (CPCIF-RA-0104).

语种：英文

外文关键词：thermoresponsive; adhesiveness; hydrogel; poly(amidoamine); wound healing

摘要：Diabetic joint wounds require dressings with strong adhesion, painless removal, and therapeutic effects. We developed DA-Hyd-Doxy, a multifunctional hydrogel, by copolymerizing N-isopropylacrylamide with dopamine-containing zwitterionic poly(amidoamine)s and encapsulating doxycycline. This hydrogel exhibits strong, reversible adhesion, surpassing the Tegaderm film at similar to 35 degrees C, while exposure to 10 degrees C water for 10 min reduces adhesion to 0 N for painless removal. It also has antioxidant and anti-inflammatory properties, promoting angiogenesis, collagen deposition, and re-epithelialization. Loaded with doxycycline, it achieves nearly 100% bacteria-killing efficiency against E. coli and S. aureus. In vivo studies showed superior wound healing, with DA-Hyd-Doxy achieving near-complete closure (1.1 +/- 0.4%) versus Tegaderm (20.2 +/- 3.0%). This hydrogel provides a practical solution for infected diabetic joint wounds, offering strong adhesion, painless removal, and multifunctional therapeutic benefits, making it ideal for dynamic wound sites.