文献类型：期刊文献

英文题名：Micro-feeding and mixing of pharmaceutical solid dosage forms under external vibration

作者：Zhang, Liang[1];Lu, Haifeng[1];Guo, Xiaolei[1];Liu, Haifeng[1,2]

机构：[1]East China Univ Sci & Technol, Natl Energy Coal Gasificat Technol Res & Dev Ctr, State Key Lab Coal Liquificat Gasificat & Utilizat, Shanghai 200237, Peoples R China;[2]Liaoning Petrochem Univ, Fushun 113005, Liaoning, Peoples R China

年份：2026

卷号：227

起止页码：97

外文期刊名：CHEMICAL ENGINEERING RESEARCH & DESIGN

收录：;EI(收录号：20260519987917);WOS:【SCI-EXPANDED(收录号:WOS:001680658000003)】；

基金：The authors acknowledge financial support from the National Nat-ural Science Foundation of China (51876066) and the Shanghai Engi-neering Research Center of Coal Gasification (18DZ2283900) .

语种：英文

外文关键词：Cohesive pharmaceutical powders; Micro feeding; Vibration excitation; Continuous manufacturing

摘要：This study addresses the challenges of micro-dosing and mixing in the continuous manufacturing of solid pharmaceutical formulations by developing a novel continuous feeding-mixing system based on external vibration excitation. The innovative design of a hopper structure with adjustable outlet area distribution demonstrated the potential for achieving precise mixing control of an active pharmaceutical ingredient (API) and an excipient across varying ratios. Experiments first validated the promotion of viscous particle flow by vertical vibration, achieving stable feeding within the range of 0.6-15 mg/s. Building on this, precise control of mixing ratios was enabled by designing different outlet area ratios. In mixing performance evaluation, online X-ray fluorescence spectroscopy confirmed the system achieves high-uniformity mixing with a coefficient of variation below 10 %. The study further revealed that optimal mixing stability occurs when Gamma < 5, whereas excessive vibration degrades mixing quality.