文献类型：期刊文献

英文题名：Functional organic nanoparticles for photodynamic therapy

作者：Rui, Lei-Lei[1];Cao, Hong-Liang[1];Xue, Yu-Dong[1];Liu, Li-Chao[1];Xu, Lei[1];Gao, Yun[1];Zhang, Wei-An[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China

年份：2016

卷号：27

期号：8

起止页码：1412

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000385327300037)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 21574039), Research Innovation Program of SMEC (No. 14ZZ065) and Shanghai Pujiang Program (No. 14PJ1402600).

语种：英文

外文关键词：Photosensitizers; Photodynamic therapy; Organic nanoparticles; Singlet oxygen; Cancer treatment

摘要：In recent years, cancer has been one of the leading causes of death in the world. Much effort has been devoted to developing cancer treatments. Photodynamic therapy (PDT) is a noninvasive therapeutic modality by combining the light of a specific wavelength, a photosensitizer (PS) and oxygen, which has been widely applied for the treatment of cancers. However, the application of PDT in clinic is greatly limited due to lack of tumor selectivity and often causing skin photosensitivity. The use of organic nanoparticles (NPs) as an advanced technology in the field of PDT shows a great promise to overcome these. shortcomings. Therefore, in this review, we summarize several functional organic NPs as PS carriers that have been developed to enhance the efficacy of PDT against cancers. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.