文献类型：期刊文献

中文题名：丹酚酸B水溶液分解反应的动力学研究

英文题名：Decomposition kinetics of salvianolic acid B's aqueous solution

作者：朱静[1];陈慧清[2];白鹏[1];倪力军[2];张立国[2]

机构：[1]天津大学化工学院,天津300072;[2]华东理工大学化学与分子工程学院,上海200237

年份：2009

卷号：31

期号：4

起止页码：541

中文期刊名：中成药

外文期刊名：Chinese Traditional Patent Medicine

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：丹酚酸B;分解反应;动力学

外文关键词：salvianolic acid B; decomposation reaction; kinetics

摘要：目的:考察丹酚酸B水溶液受热分解的反应动力学行为。方法:采用高效液相色谱测定不同温度、pH值及加热时间下丹酚酸B水溶液中丹酚酸B的含量,关联丹酚酸B浓度与加热时间的关系。结果:丹酚酸B水溶液分解反应为一级反应,其中温度对丹酚酸B分解反应速率的影响大于pH值,而在较低温度(50℃)下,丹酚酸B分解反应速率常数很低,随pH值变化幅度不大。结论:在丹参水提制备丹酚酸B的过程中应避免高温、碱性条件下长时间加热,可减少丹酚酸B的损失和分解,提高提取物中丹酚酸B的含量。
AIM： To study the decomposition reaction kinetics of aqueous salvianolic acid B （Sal B）. METHODS ： HPLC was applied to determine Sal B＇ s content of samples. Relationship between Sal B＇s content and heating time was regressed. RESULTS： Decomposition reaction of Sal B＇ s aqueous solution was first order reaction. The effect of temperature on reaction rate of Sal B＇s decomposition was higher than pH value. At lower temperature （ 50℃ ） , reaction rate constant K of Sal B＇ s decomposition was very low and it changed very little with pH values. CONCLUSION： Water extraction process of Salvia Militiorrhiza should avoid applying high temperature, alkaline condition and long heating time in order to reduce loss and decomposition of Sal B, and then also increase Sal B＇ s content in the extract.