文献类型：期刊文献

中文题名：蔗糖羟基的选择性保护

英文题名：Selective Hydroxyl Protected Reaction of Sucrose

作者：吴福忠[1];蔡水洪[2];冯卫青[2];邢领俊[2]

机构：[1]华东理工大学化工学院,上海200237;[2]上海东岳生物化工有限公司,上海200237

年份：2008

卷号：34

期号：5

起止页码：631

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;EI(收录号：20084811740412);Scopus;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：蔗糖;三苯基氯甲烷;吡啶;甲苯;羟基保护

外文关键词：sucrose; trityl chloride; pyridine; toluene; hydroxyl protected

摘要：以三苯基氯甲烷和乙酸酐依次对蔗糖的8个羟基进行选择性保护,考察了反应配比、温度、溶剂对蔗糖保护过程的影响。结果表明:以吡啶替代二甲基甲酰胺(DMF)和N-甲基吗啉作为溶剂和缚酸剂的伯羟基醚化反应,选择性为78%,三苯甲醇收率达98%以上,以甲苯为萃取剂和乙酰化反应的溶剂,避免了除杂过程的液固分离和固固分离,反应平稳,催化剂可循环使用,蔗糖全基团保护物(TRISPA)的收率达到75%。
Selective hydroxyl protected reaction of sucrose by trityl chloride and acetic anhydride was investigated. The intluence of solvent, temperature and mole ratio of material on the protected process were discussed. The results show that using pyridine as solvent and removal acid reagent instead of DMF and N-methylmorpholine, the selectivity of 6,1′,6′-ether sucrose is 78% and the yield of tritonal is more than 98%. After extraction with toluene, the catalyst can be recycled and the reaction is stable, the yield of TRISPA is 75 %.