文献类型：期刊文献

英文题名：Synthesis and properties of Pluronic-based pentablock copolymers with pendant amino groups

作者：Zhang, Yan[1];Zhao, Li[1];Chen, Min[2];Lang, Meidong[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Minist Educ,Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Bioengn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2013

卷号：291

期号：7

起止页码：1563

外文期刊名：COLLOID AND POLYMER SCIENCE

收录：;EI(收录号：20132716461323);WOS:【SCI-EXPANDED(收录号:WOS:000320578000002)】；

基金：Financial support from the National Natural Science Foundation of China (20804015), the Fundamental Research Funds for the Central Universities (WD0913008, WD1014036), and Shanghai Key Laboratory Project (08DZ2230500) are gratefully acknowledged.

语种：英文

外文关键词：Pendant amino groups; Pluronic; Poly(epsilon-caprolactone); Micelles

摘要：Amphiphilic Pluronic-based pentablock copolymers with pendant amino groups have been successfully synthesized via ring opening polymerization of gamma-(carbamic acid benzyl ester)-epsilon-caprolactone (gamma CAB epsilon CL) and epsilon-caprolactone (epsilon CL) using Pluronic F127 as macroinitiator and Sn(Oct)(2) as catalyst, and followed by hydrolysis of the Cbz protected groups under acidic conditions. The structure of the copolymer was confirmed by proton nuclear magnetic resonance (H-1 NMR) and Fourier transform infrared spectroscopy spectra. In addition, gel permeation chromatography results demonstrated that the synthetic copolymer had a single and symmetrical peak. Moreover, the crystallinity and hydrophilicity could be well adjusted by the content of the functionalized monomer. Successful formation of aggregates was demonstrated by fluorescence method and transmission electron microscopy revealed that the micelles had a spherical morphology and the size was on nano scale according to the laser particle sizer results. The polymeric micelles had no obvious cytotoxicity even the micelles concentration reached 500 mg/L. Thus the Pluronic-b-poly(gamma-amino-epsilon-caprolactone-co-epsilon-caprolactone) copolymers have great potential for the use in the biomedical fields.