文献类型：期刊文献

中文题名：中国鱼类疫苗技术研发及应用研究进展

英文题名：Fish vaccine technology development and application in China:a review

作者：王启要[1]

机构：[1]华东理工大学生物反应器工程国家重点实验室,上海海洋动物疫苗工程技术研究中心,农业农村部水生动物疫病专业实验室,上海200237

年份：2022

卷号：37

期号：1

起止页码：1

中文期刊名：大连海洋大学学报

外文期刊名：Journal of Dalian Ocean University

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金(32130108,31772891,31772893);财政部和农业农村部:国家现代农业产业技术体系资助(CARS-47)。

语种：中文

中文关键词：疫苗;新兽药;养殖鱼类;病害防控

外文关键词：vaccine;new veterinary drug;farmed fish;diseases control

摘要：随着水产养殖业高密度、规模化、集约化高速发展,病害已成为产业健康可持续发展的重大挑战。鱼类接种疫苗既可以防控水产病害发生、减少产业的经济损失,又可以减少或消除由于大量使用抗生素带来的健康危害、生态风险和水产品食品安全等问题,从而支撑水产养殖业健康、绿色发展。本文综述了目前国内外鱼类疫苗开发中包括灭活疫苗、减毒/弱毒活疫苗、亚单位/合成肽疫苗和DNA疫苗在内的主要技术策略及相应的接种、递送方式,着重介绍了已经获得中国新兽药证书的9个鱼类疫苗及其应用,以及中国鱼类疫苗审批管理的情况。针对中国高效鱼类疫苗品种供给不足和开发进程漫长等问题,提出了未来应加强鱼类病原与病害相关的基础研究、利用多组学技术推进高效鱼类疫苗的分子设计及构建鱼类疫苗工程研究技术平台等鱼类疫苗工程领域的重点研究方向。
Aquaculture industries have witnessed large-scale,intensive,professional quick development and diseases outbreaks greatly threaten the healthy sustainable development of the industries.Vaccination can not only prevent and control aquatic diseases,reduce the economic loss of aquaculture industry,but also reduce the health hazards and ecological risks brought about by overuse and abuse of antibiotics,which meets the needs of green development of aquaculture industry in China.We reviewed the main stream technologies used for the development,and inoculation strategies and associated delivery methods of vaccines against piscine species,e.g.inactivated vaccines,live attenuated or live avirulent vaccines,subunit vaccines or synthetic peptide vaccine,as well as DNA vaccines.Nine vaccines related to aquatic diseases that have been fully licensed new veterinary drug registration's certificate in China are described.The overview of administration management of Chinese aquaculture and aquatic vaccines is also introduced in recent years.In addition,the future prospects of development and engineering of piscine vaccines are discussed,including the basic research for fish pathogens and diseases control,molecular design of fish vaccines by leveraging multi-omics technologies,and construction of piscine vaccine engineering and technology platform to facilitate to provide effective vaccines for diseases control in China aquaculture industries.