文献类型：期刊文献

英文题名：Novel porous silica granules for instant hemostasis

作者：Hong, Hua[1,2,3];Wang, Chengwei[1,2];Yuan, Yuan[1,3];Qu, Xue[1,2];Wei, Jie[1,2];Lin, Zhaofen[3];Zhou, Huayi[1,2];Liu, Changsheng[1,2,3]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[3]Second Mil Med Univ, Shanghai 200433, Peoples R China

年份：2016

卷号：6

期号：82

起止页码：78930

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20163602774585);WOS:【SCI-EXPANDED(收录号:WOS:000382539300082)】；

基金：We acknowledge the financial support from the National Basic Research Program of China (973Program, No. 2012CB933600), National Science and Technology Support Program (2014BAK05B02) and the 111 Project (B14018).

语种：英文

外文关键词：Silica - Mesoporous materials - Water absorption

摘要：For emergency control of bleeding, there is a strong demand for topical hemostatic materials that can not only stop bleeding rapidly but also be carried and used conveniently. The aim of this work was to develop a novel type of porous silica material and investigate its hemostatic performance. The porous silica spherical-like granules were prepared via dry-mixing and wet-granulation with diameters of 0.40-1.10 mm. Granulation reinforced the infiltrating ability of the porous silica materials with fluid and stabilized their capillary structure. The rapid water absorption ability was enhanced 130% for the porous silica granules compared to the mesoporous silica particles. In vitro coagulation studies showed the clotting time of blood was shorten greatly from 150 seconds for mesoporous silica particles to 30 seconds for mesoporous silica granules at the early stage of hemostasis. In vivo studies using a rat injury model demonstrated the granules' ability to aid in rapid hemostasis. The usability of silica material was improved significantly by granulation through enhancing its flowability and eliminating dust. This study suggested the porous silica granules are a good candidate as a hemostatic agent in clinical and family applications.