文献类型：期刊文献

英文题名：Direct Transformation of Simple Enals to 3,4-Disubstituted Benzaldehydes under Mild Reaction Conditions via an Organocatalytic Regio- and Chemoselective Dimerization Cascade

作者：Song, Xixi[2];Zhang, Xinshuai[2];Zhang, Shilei[2];Li, Hao[1];Wang, Wei[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2012

卷号：18

期号：32

起止页码：9770

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20123215306299);WOS:【SCI-EXPANDED(收录号:WOS:000306921600002)，CCR-EXPANDED(收录号:WOS:000306921600002)】；

基金：Financial support from the Chinese National Science Foundation (CHE-1057569 to W. W.), the Chinese Ministry of Education through the "Program of Introducing Talents of Discipline to Universities" (111 Project) (grant no. B07023), the East China University of Science and Technology through the Shanghai Pujiang Program (11 J1411900 to H. L.), and the Shanghai Committee of Science and Technology ( grant no. 11DZ2260600) is gratefully acknowledged.

语种：英文

外文关键词：arenes; aromatization; cascade reactions; dimerization; organocatalysis

摘要：Straight to the point: An organocatalyzed, direct preparation of 3,4-disubstituted benzaldehydes from simple enals under mild conditions without the need for an additional oxidant has been developed. Notably, self-dimerization of an enal precursor and cross-dimerization of two distinct enals have been realized with high regio- and chemoselectivity to give structurally diverse 3,4-substituted benzaldehydes in good yields (76-99 %). Copyright ? 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.