文献类型：期刊文献

英文题名：Helical supramolecular polymer nanotubes with wide lumen for glucose transport: towards the development of functional membrane-spanning channels

作者：Zhang, Chenyang[1];Deng, Xiaoli[1];Wang, Chenxi[2];Bao, Chunyan[2];Yang, Bing[1];Zhang, Houyu[1];Qi, Shuaiwei[1];Dong, Zeyuan[1]

机构：[1]Jilin Univ, State Key Lab Supramol Struct & Mat, Coll Chem, Qianjin St, Changchun, Jilin, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Inst Fine Chem, 130 Meilong Rd, Shanghai, Peoples R China

年份：2019

卷号：10

期号：37

起止页码：8648

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20194007484426);WOS:【SCI-EXPANDED(收录号:WOS:000487674500014)】；

基金：This work was supported by the Natural Science Foundation of China (No. 21574054 and 21722403) and the Program for JLU Science and Technology Innovative Research Team (JLUSTIRT) (No. 2019TD-36).

语种：英文

外文关键词：Supramolecular chemistry - Hydrogen bonds - Ions - Lipid bilayers - Molecular dynamics - Nanotubes - Topology

摘要：The manipulation of strong noncovalent interactions provides a concise and versatile strategy for constructing highly ordered supramolecular structures. By using a shape-persistent building block consisting of phenanthroline derivatives and two quadruply hydrogen-bonding AADD moieties, a type of precise helical supramolecular polymer (HSP) nanotube has been developed. The helical conformation of the supramolecular polymers has been proved via various techniques, showing significantly expanded topologies of supramolecular polymers. From the production of new topological structures of supramolecular polymers, predictable properties and functions have arisen. In this study, the helical folding of supramolecular polymers gave rise to the generation of specific wide lumen structures that can be directly visualized via TEM, and the resulting HSP nanotubes can puncture the lipid bilayer membrane to facilitate the transportation of glucose.