文献类型：期刊文献

英文题名：Aptamer Functionalized Hydrogel Dressings for Post-Surgery Tumor Recurrence Inhibition and Tissue Reconstruction

作者：Li, Tianyue[1];Qian, Xin-Yi[2];Li, Zi-Yuan[1];Li, Hao-Wen[3];Tan, Poh-Ching[2];Hu, Chenghuizi[1];Jin, Jiajun[1];Zhou, Shuang-Bai[2];Li, Qing-Feng[2];Tian, He[1];Zhang, Junji[1];Willner, Itamar[1,4]

机构：[1]East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem,Key Lab, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, Shanghai 200011, Peoples R China;[3]Chinese Acad Sci, Hangzhou Inst Med, Hangzhou 310000, Peoples R China;[4]Hebrew Univ Jerusalem, Inst Chem, Ctr Nanosci & Nanotechnol, IL-91904 Jerusalem, Israel

年份：2025

卷号：35

期号：47

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20252418598136);WOS:【SCI-EXPANDED(收录号:WOS:001503163100001)】；

基金：T.L. and X.Q. contributed equally to this work. This work was supported by National Natural Science Foundation of China (22122803, 22378121, 22105070), Science and Technology Commission of Shanghai Municipality (24DX1400200), the Fundamental Research Funds for the Central Universities (222201717003). JZ acknowledges the Shanghai Natural Science Foundation Project (23ZR1479500, 23JC1401700). ZL acknowledges the Shanghai Sailing Program (20YF1410300).

语种：英文

外文关键词：DNA aptamer; hydrogels; oligonucleotide; tumor inhibition; wound healing

摘要：Tumor post-surgical therapy faces two critical challenges of local tumor recurrence and tissue repairing. Residual tumor cells pose a significant risk for recurrence and metastasis, while post-operative wound complications hinder patient recovery. Inflammatory responses from surgical trauma further exacerbate tumor regrowth and delay healing. Hydrogels, particularly DNA-based hydrogels, emerge as promising biomaterials for regenerative medicine. Their unique properties, including biocompatibility, programmability, and specific molecular recognition, make them suitable candidates for dual-function wound dressings. In this study, DNA aptamer-functionalized gelatin (Apt-GelMA) hydrogels are developed incorporating anti-HGF c-Met and anti-EGFR CL-4 aptamers. The Apt-GelMA hydrogel significantly suppresses local tumor regrowth while accelerating wound healing through enhanced cell adhesion and migration. Additionally, after attaching aptamers to the polymer chains, their stability or resistance to degradation is greatly improved. The results demonstrate Apt-GelMA as a promising post-surgical dressing with dual therapeutic functions, offering future potential clinical applications.