文献类型：期刊文献

英文题名：Activatable near-infrared emission-guided on-demand administration of photodynamic anticancer therapy with a theranostic nanoprobe

作者：Wang, Rongchen[1,2];Dong, Kaikai[3];Xu, Ge[1,2];Shi, Ben[1,2];Zhu, Tianli[1,2];Shi, Ping[3];Guo, Zhiqian[1,2];Zhu, Wei-Hong[1,2];Zhao, Chunchang[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：10

期号：9

起止页码：2785

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20191006584624);WOS:【SCI-EXPANDED(收录号:WOS:000459929800024)】；

基金：We gratefully acknowledge the financial support by the National Science Foundation of China (grant numbers 21672062, 31671309).

语种：英文

外文关键词：Diseases - Photodynamic therapy - Diagnosis - Infrared devices

摘要：Development of theranostic probes that can be used to identify tumors and direct the on-demand drug administration to cancers is ongoing but remains challenging. Herein, we report a theranostic platform composed of a H2S-activated imaging probe and a light-sensitive drug. The designed probe affords advantages of H2S-activated NIR emission light- up and efficient O-1(2) generation, enabling the selective visualization of H2S-rich cancers and the subsequent imaging-directed on-demand light exposure to the detected cancers while leaving normal tissues untouched. Such controllable administration of photodynamic anticancer therapy maximizes the therapeutic efficiency and minimizes side effects. This work should facilitate significant advances toward precise diagnosis and treatment of cancer.