文献类型：期刊文献

英文题名：Controlled synthesis and transformation of nano-hydroxyapatite with tailored morphologies for biomedical applications

作者：Ma, Xiaoyu[1,2];Li, Yuanyuan[3];Wang, Chengwei[1,2];Sun, Yi[3];Ma, Yifan[1,2];Dong, Xiuling[3];Qian, Jiangchao[3];Yuan, Yuan[1,2,3];Liu, Changsheng[1,2,3]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China

年份：2017

卷号：5

期号：46

起止页码：9148

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20174904510982);WOS:【SCI-EXPANDED(收录号:WOS:000416558400008)】；

基金：This work was supported by grants from the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), the National Natural Science Foundation of China (No. 31330028 and 31470924), and the 111 Project (B14018).

语种：英文

外文关键词：Microemulsions - Hydroxyapatite - Nanocomposites - Medical applications

摘要：Hydroxyapatites (HAps) with nano-sized structures are promising materials in various biomedical areas, but the synthesis of high quality particles is still challenged by the insufficient precision of size and morphology, as well as the presence of severe agglomeration. An inadequate knowledge of the early nucleation, growth and transformation might limit our exploration and application of HAp. Here, we report a novel oil/water microemulsion-hydrothermal hybrid strategy for the preparation of highly dispersive HAps with tailored morphologies and controlled size. Through the synergetic effect of the oleic acid and microemulsion system, a well-dispersed HAp nucleus was first generated at 2 h. By tuning the ensuing hydrothermal conditions from room temperature to 140 degrees C, the nucleus would grow from spherical to needle-like nanoparticles. The size of the particles could be regulated by the alteration of the hydrothermal temperature. In addition, we experimentally demonstrated the complete evolution of HAp growth and transformation at a critical temperature of 90 degrees C by quenching the reaction at various intervals. The obtained particles were explored as potential cellular delivery carriers and polymer fillers.