文献类型：期刊文献

英文题名：Effect of sulfated chitosan hydrogel on vascularization and osteogenesis

作者：Jiang, Ming[1,2,3];Pan, Yuanzhong[1,2,3];Liu, Yuanda[1,2,3];Dai, Kai[1,2,3];Zhang, Qinghao[1,2,3];Wang, Jing[1,2,3,4]

机构：[1]East China Univ Sci & Technol, Mat Sci & Engn Sch, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2022

卷号：281

外文期刊名：CARBOHYDRATE POLYMERS

收录：;EI(收录号：20220211433356);WOS:【SCI-EXPANDED(收录号:WOS:000760902100004)】；

基金：The authors would like to express their gratitude for the financial support from the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002) , the National Natural Science Foundation of China (31870953) , and Shanghai Pujiang Program 18PJ1402400.

语种：英文

外文关键词：Sulfated chitosan; Mesenchymal stem cells; Bone regeneration; Vascularization

摘要：Bone regeneration and vascularization have presented a clinical challenge for decades. Considering the importance of stem cells, such as mesenchymal stem cells (MSCs), in bone regeneration, endothelial progenitor cells (EPCs) are crucial during bone repair. This paper presented sulfated chitosan (SCS)-based hydrogel scaffolds to accelerate bone tissue regeneration, vascularization enhancement, and improve bone repair. Thus, these scaffolds played a crucial role in the regeneration of blood vessels, with the increased presentation of epithelial progenitors and immune cells in this microenvironment. In vivo experiments showed that the biological impact of SCS was critical for angiogenesis and vascularization, in conjunction with bone morphogenetic protein-2 (BMP2) and MSCs. Therefore, the BMP-2-/hydrogel system established in this study promoted angiogenesis, stimulated MSC proliferation, and enhanced bone tissue formation. In addition, this paper highlighted the angiogenic role of SCS in creating a micro-environment for effective bone repair and provides insight into the future development of new bone regeneration material.