文献类型：期刊文献

英文题名：A Stimuli-Responsive Nanopore Based on a Photoresponsive Host-Guest System

作者：Ying, Yi-Lun[1,2];Zhang, Junji[1,2];Meng, Fu-Na[1,2];Cao, Chan[1,2];Yao, Xuyang[1,2];Willner, Itamar[3,4];Tian, He[1,2];Long, Yi-Tao[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China;[3]Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel;[4]Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, IL-91904 Jerusalem, Israel

年份：2013

卷号：3

外文期刊名：SCIENTIFIC REPORTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000317576800003)】；

基金：This work was supported by the National Base Research 973 Program (2013CB733700). Y.-T.L. is supported by the National Science Fund for Distinguished Young Scholars of China (21125522) and (SKLEAC201305). Y.-L.Y. is supported by the Sino-UK Higher Education Research Partnership for PhD Studies. We thank Mr. Shuaifan Wu for the discussions on synthesis procedures.

语种：英文

摘要：The open-close states of the ion channels in a living system are regulated by multiple stimuli such as ligand, pH, potential and light. Functionalizing natural channels by using synthetic chemistry would provide biological nanopores with novel properties and applications. Here we use para-sulfonato-calix[4] arene-based host-guest supramolecular system to develop artificial gating mechanisms aiming at regulating wild-type alpha-HL commanded by both ligand and light stimuli. Using the gating property of alpha-hemolysin, we studied the host-guest interactions between para-sulfonato-calix[4] arene and 4, 4'-dipyridinium-azobenzene at the single-molecule level. Subsequently, we have extended the application of this gating system to the real-time study of light-induced molecular shuttle based on para-sulfonato-calix[4] arene and 4, 4'-dipyridinium-azobenzene at the single-molecule level. These experiments provide a more efficient method to develop a general tool to analyze the individual motions of supramolecular systems by using commercially available alpha-HL nanopores.