文献类型：期刊文献

英文题名：Polyphenol-mediated biomimetic mineralization of sacrificial metal-organic framework nanoparticles for wound healing

作者：Zhan, Xiaolong[1];Wen, Zhengbo[2,3];Chen, Xi[4];Lei, Qi[1];Chen, Yuxin[2,3];Zhou, Liang[1];Zheng, Guansheng[1];Kong, Fanhui[1];Guo, Jimin[5];Duan, Yuyou;Lai, Yuyan[6];Yin, Panchao[6];Brinker, C. Jeffrey[5];Chen, Honglin[2,3];Zhu, Wei[1]

机构：[1]South China Univ Technol, Sch Biol & Biol Engn, MOE Int Joint Res Lab Synthet Biol & Med, Guangzhou 510006, Peoples R China;[2]South China Univ Technol, Inst Life Sci, Lab Stem Cells & Translat Med, Guangzhou 510006, Peoples R China;[3]South China Univ Technol, Sch Med, Guangzhou 510006, Peoples R China;[4]East China Univ Sci & Technol, Engn Res Ctr Biomat, Frontiers Sci Ctr Mat & Dynam Chem, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[5]Univ New Mexico, Dept Chem & Biol Engn, Ctr Microengn Mat, Albuquerque, NM 87131 USA;[6]South China Univ Technol, Sch Mol Sci & Engn, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China

年份：2022

卷号：3

期号：11

外文期刊名：CELL REPORTS PHYSICAL SCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000907248200002)】；

基金：Supported by the National Natural Science Foundation of China (32071360, 31900976, 21972047, and 52003086), Guangdong Provincial Pearl River Talents Program (2019QN01Y314), the Program for Guangdong Introducing Innovative and Entrepreneurial Teams (2019ZT08Y318), Natural Science Foundation of Guangdong Province, China (2021A1515010724 and 2021A1515220051), and the Science and Technology Project of Guangzhou, China (202102020352 and 202102020259).

语种：英文

摘要：Mineralization is a natural process that constructs intricate structures at diverse interfaces, but with poor controllability. Herein, we present an alternative strategy for dynamic control of nano-scale mineralization processes and the subsequent construction of an all-in-one healing agent to meet the requirements of wound healing with complex physiological processes. The key point is the reversible metal-polyphenol coordination, where polyphenol acts as a capping agent to stabilize the mineralized precursor solution. Upon combination with metal-organic frameworks (MOFs) that can competitively capture polyphenol from solution to disrupt the balance of stabilized precursors, the released mineral ions result in fast mineralization on MOF surface. The mineralized metal-phenolic frameworks feature plug-and-play properties. After being loaded into a gelatin-chitosan hydrogel, the composite hydrogel exhibits antibacterial and anti-inflammatory effects while promoting angiogenesis, collagen deposition, and hair follicle regeneration. The mineralization strategy could also be applied to thin film technology for a range of applications.