文献类型：期刊文献

英文题名：Diastereo- and Enantioselective Synthesis of Oxazine and Oxazolidine Derivatives with a Chiral Quaternary Carbon Center under Multifunctional Catalysis

作者：Jin, Zhichao[1];Wang, Xiao[1];Huang, Huicai[1];Liang, Xinmiao[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

年份：2011

卷号：13

期号：4

起止页码：564

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000287122800006)，CCR-EXPANDED(收录号:WOS:000287122800006)】；

基金：This work was supported by the National Natural Science Foundation of China (20902018), the Fundamental Research Funds for the Central Universities, the Shanghai Pujiang Program (08PJ1403300), and the Innovation Program of Shanghai Municipal Education Commission (11ZZ56).

语种：英文

摘要：An easy one-pot, multistep cascade reaction which could afford a series of substituted benzo[d]pyrido[2,1-b]oxazolidine and [1,3]oxazine derivatives in a highly enantio- (up to 98% ee) and diastereoselective (4:1 to >20:1 dr) manner with generally good to excellent yields (up to 99%) has been developed. This well designed strategy could be applied to a wide scope of substrates under mild conditions with simple operations.