文献类型：期刊文献

英文题名：Raman/fluorescence dual-sensing and imaging of intracellular pH distribution

作者：Cao, Yue;Qian, Ruo-Can;Li, Da-Wei;Long, Yi-Tao[1]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：51

期号：99

起止页码：17584

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000366322500019)】；

基金：This research was supported by the National Basic Research 973 Program (2013CB733700), NSFC (21125522, 21327807, 21575041), the Shanghai Pujiang Program Grant of China (12JC1403500), the Shanghai Municipal Natural Science Foundation (14ZR1410800), the Fundamental Research Funds for the Central Universities (WB1113005) and the China Postdoctoral Science Foundation (2015M570335).

语种：英文

摘要：Herein, a pH-sensitive probe has been designed based on DNA modified gold nanoparticles (AuNPs) for Raman/fluorescence dual-imaging of the intracellular pH distribution. In the acidic environment of cancer cells, the configuration change of DNA on the probe surface could turn "on'' Raman/fluorescence signals simultaneously.