文献类型：期刊文献

英文题名：A NaH-promoted N-detosylation reaction of diverse p-toluenesulfonamides

作者：Sun, Wanwan[1,2];Chen, Xiaobei[3,4];Hu, Ying[5];Geng, Huihui[3,4];Jiang, Yuanrui[1,2];Zhou, Yuxin[1,2];Zhu, Wenjing[1,2];Hu, Min[1,2];Hu, Haohua[1,2];Wang, Xingyi[1,2];Wang, Xinli[1,2];Zhang, Shilei[1,2];Hu, Yanwei[1,2]

机构：[1]Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;[2]Soochow Univ, Coll Pharmaceut Sci, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[5]Suzhou Vocat Hlth Coll, Dept Pharm, 28 Kehua Rd, Suzhou 215009, Peoples R China

年份：2020

卷号：61

期号：43

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000579003400012)，CCR-EXPANDED(收录号:WOS:000579003400012)】；

基金：This work was supported by National Natural Science Foundation of China (21202112 and 21702058), PAPD (A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions) and East China University of Science and Technology, the '111' Project. We are also grateful to the financial supports from Suzhou Vocational Health College, Qing Lan Project of Jiangsu Province.

语种：英文

外文关键词：Sodium hydride; Detosylation; P-toluenesulfonamides; Indole

摘要：A NaH-mediated detosylation reaction of various Ts-protected indoles, azaheterocycles, anilines and dibenzylamine was reported. The method features cheap reagent, convenient operations, mild reaction conditions and broad substrate scope. Moreover, this study revealed that the loading of NaH in tosylation reactions of nitrogen-containing compounds with NaH as a base in DMA or DMF should be controlled due to the possibility of adverse detosylation. (C) 2020 Elsevier Ltd. All rights reserved.