文献类型：期刊文献

英文题名：Organ-on-a-chip platforms for accelerating the evaluation of nanomedicine

作者：Chen, Xi[1];Zhang, Yu Shrike[2];Zhang, Xinping[1];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomat, Key Lab Ultrafine Mat,Minist Educ,Sch Mat Sci & E, Shanghai 200237, Peoples R China;[2]Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA

年份：2021

卷号：6

期号：4

起止页码：1012

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000616630300010)】；

基金：This work was primarily leveraged by National Natural Science Foundation of China for Innovative Research Groups (No. 51621002). Y. S.Z. was not supported by this fund; instead, support by the Brigham Research Institute is thanked. We acknowledge Dr. Amy Wen and Ms. Xuewei Zhang for helpful discussion. Any opinions, findings, conclusions, or recommendations expressed herein are those of the author(s).

语种：英文

外文关键词：Microfluidics; Nanoparticles; Nano-bio interaction; Body-on-a-chip; 3D cell culture model

摘要：Nanomedicine involves the use of engineered nanoscale materials in an extensive range of diagnostic and therapeutic applications and can be applied to the treatment of many diseases. Despite the rapid progress and tremendous potential of nanomedicine in the past decades, the clinical translational process is still quite slow, owing to the difficulty in understanding, evaluating, and predicting nanomaterial behaviors within the complex environment of human beings. Microfluidics-based organ-on-a-chip (Organ Chip) techniques offer a promising way to resolve these challenges. Sophisticatedly designed Organ Chip enable in vitro simulation of the in vivo microenvimnments, thus providing robust platforms for evaluating nanomedicine. Herein, we review recent developments and achievements in Organ Chip models for nanomedicine evaluations, categorized into seven broad sections based on the target organ systems: respiratory, digestive, lymphatic, excretory, nervous, and vascular, as well as coverage on applications relating to cancer. We conclude by providing our perspectives on the challenges and potential future directions for applications of Organ Chip in nanomedicine.