文献类型：期刊文献

中文题名：反应型甲醛小分子荧光探针进展

英文题名：Reaction-Based Formaldehyde Small Molecule Fluorescent Probes

作者：徐清爽[1];郭志前[1]

机构：[1]华东理工大学精细化工研究所

年份：2019

卷号：45

期号：3

起止页码：357

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD_E2019_2020】；

语种：中文

中文关键词：甲醛;荧光探针;再生;响应机理

外文关键词：formaldehyde;fluorescent probe;regeneration;sensing mechanism

摘要：甲醛是一种具有高度反应活性的羰基物种,基于其活性羰基与识别基团的反应类型对其进行分类,概述了NH2基团反应型、NHNH2基团反应型、Aza-Cope重排反应型以及待测物再生型甲醛荧光探针的反应机理,重点对再生型甲醛荧光探针的设计进行了亮点评述。从甲醛分子探针的设计理念、识别机理以及应用等方面进行了描述,最后对新型甲醛分子探针的设计与发展提出了展望。
Formaldehyde (FA) is one of the simplest reactive carbonyl species (RCS). Aberrant accumulation of formaldehyde in patients implicates not only in diverse physiological processes but also in various pathological processes, including neurodegenerative diseases, diabetes, chronic liver and heart disorders. In addition, some RCS in the environment are pollutants that threaten human health. Consequently, the development of sensitive methods, which can selectively monitor RCS in live cells, tissues and organisms as well as in environmental samples, is highly demand so that their biological roles could be understood and their concentrations in environmental samples can be determined. Recently, fluorescence as a powerful tool has attracted great interest in the design of high-performance sensors for in vitro and in vivo tracking formaldehyde. This article briefly describes the classification of fluorescent reaction-based probes for formaldehyde that rely on the reactive carbonyl of formaldehyde and the recognition unit, NH2 group, NHNH2 group, Aza-Cope rearrangement reaction and the new type of regeneration fluorescent probes. In particular, the latest formaldehyde regeneration fluorescent probe is highlighted, which firstly captures the analyses, induces imide bond cleavage, and then releases the captured formaldehyde molecule with simultaneous off-on fluorescence response. This article summarizes the formaldehyde-based fluorescent probes from the aspects of design concept, recognition mechanism and application.