文献类型：期刊文献

英文题名：Design, Synthesis, and Insecticidal Evaluation of Neonicotinoids with Conjugated Diene

作者：Wang, Yiping[1];Zhang, Xiao[1];Kong, Yijin[1];Yang, Wu-Lin[1];Xu, Zhiping[1];Cheng, Jiagao[1];Shao, Xusheng[1];Xu, Xiaoyong[1];Li, Zhong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai 200237, Peoples R China

年份：2023

卷号：71

期号：30

起止页码：11332

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20233214485083);WOS:【SCI-EXPANDED(收录号:WOS:001030163100001)】；

基金：This research was supported by the National Key Research and Development Program of China (2017YFD0200500) and the Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-02-E00037).

语种：英文

外文关键词：neonicotinoid insecticides; insect nicotinic acetylcholinereceptors; conjugated diene; density functionaltheory; molecular docking

摘要：Neonicotinoid insecticides acting on the insect nicotinicacetylcholinereceptors (nAChRs) play an essential role in contemporary pest control.In the present study, a series of novel neonicotinoid analogues withconjugated diene were synthesized. Bioassays indicated that compounds A3 and A12 had LC50 values of 1.26and 1.24 mg/L against Myzus persicae, respectively, which were comparable to that of imidacloprid (IMI,LC50 = 0.78 mg/L). Density functional theory (DFT) calculationswere performed to explain the differences in the insecticidal activitiesof target compounds. Molecular docking results indicate that compounds A3 and A12 interact favorably with Lymnaea stagnalis AChBP. The hydrolysis experimentsconfirmed that the stability of compounds A3 and A12 was enhanced in water.