文献类型：期刊文献

英文题名：Synthesis of Symmetric 1,4-Diamino-2-Butynes via a Cu(I)-Catalyzed One-Pot A³-Coupling/Decarboxylative Coupling of a Propiolic Acid, an Aldehyde, and an Amine

作者：Feng, Huangdi[1,2];Ermolat'ev, Denis S.[1];Song, Gonghua[2];Van der Eycken, Erik V.[1]

机构：[1]Katholieke Univ Leuven, Lab Organ & Microwave Assisted Chem, Dept Chem, B-3001 Louvain, Belgium;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2012

卷号：77

期号：11

起止页码：5149

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000304682400030)，CCR-EXPANDED(收录号:WOS:000304682400030)】；

基金：We thank the FWO (Fund for Scientific Research-Flanders (Belgium)) and the Research Fund of the University of Leuven for financial support to the laboratory. D.S.E. is grateful to the FWO for a postdoc fellowship. H.F. thanks the China Scholarship Council for financial support.

语种：英文

摘要：A novel microwave-assisted approach for the one-pot Cu(I)-catalyzed A(3)-coupling/decarboxylative coupling (PA(2)-coupling) of a propiolic acid, an aldehyde, and an amine, resulting in the formation of diversely substituted 1,4-diamino-2-butynes, is described. It is noteworthy that this new multicomponent coupling provides an efficient access to introduce alkyl and aryl group at the 1,4-position of the 1,4-diamino-2-butynes.