文献类型：期刊文献

英文题名：Ivermectin induced early developmental damage to the nervous system of zebrafish larvae

作者：Jiang, Yixuan[2];Su, Lin[1];Peng, Bo[1];Wang, Weiguo[1];Zhang, Yang[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]United World Coll South East Asia Dover, Singapore 139654, Singapore

年份：2025

卷号：116

外文期刊名：ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001500473400001)】；

基金：The authors gratefully acknowledge the funding from the National Natural Science Foundation of State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025 China (SKL-GPL-KF-202404) and the Fundamental Research Funds for the Central Universities (China) .

语种：英文

外文关键词：Ivermectin; Zebrafish; Neurological development; Safety evaluation

摘要：Ivermectin has good antiparasitic activity and is heavily used in animal husbandry. However, its extensive use puts pressure on the environment. This study focused on evaluating the safety of ivermectin on the nervous system of aquatic organisms. The effects of ivermectin on the neurological development of zebrafish larvae were mainly explored. The results showed that ivermectin was able to induce developmental abnormalities in zebrafish larvae, which were mainly manifested as head edema. Further results showed that zebrafish larvae had reduced cellular densities and decreased numbers of neuronal cells in the brain. Ivermectin also impaired neural crest development and induced apoptosis. In locomotor behavior, ivermectin induced diminished locomotion in zebrafish larvae. Finally, the results showed that ivermectin was able to induce abnormal expression of genes related to neural development in zebrafish larvae. This study hopes to draw more attention to the safety of ivermectin for aquatic organisms.