文献类型：期刊文献

英文题名：A Strategy Enabling Enantioselective Direct Conjugate Addition of Inert Aryl Methane Nucleophiles to Enals with a Chiral Amine Catalyst under Mild Conditions

作者：Li, Tengfei[1,2];Zhu, Jin[1,2];Wu, Deyan[1,2];Li, Xiangmin[1,2];Wang, Sinan[1,2];Li, Hao[1,2];Li, Jian[1,2];Wang, Wei[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2013

卷号：19

期号：28

起止页码：9147

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20132816495294);WOS:【SCI-EXPANDED(收录号:WOS:000325849000013)，CCR-EXPANDED(收录号:WOS:000325849000013)】；

基金：Financial support of this research provided by the National Natural Science Foundation of China (Grant 21222211, J.L.), the National S&T Major Project of China (Grant 2011ZX09102-005-02, J.L.), the Shanghai Committee of Science and Technology (Grant 11DZ2260600, J.L.), the Fundamental Research Funds for the Central Universities (J.L.), the China 111 Project (Grant B07023, J.L and W.W.), East China University of Science & Technology (W.W.), and the National Science Foundation (CHE-1057569, W.W.) is gratefully acknowledged.

语种：英文

外文关键词：aryl methane; enals; iminium catalysis; Michael addition; organocatalysis

摘要：Nitro-charged activation: An organocatalytic enantioselective conjugate addition of aryl methyl nucleophiles to enals has been developed to produce ubiquitous chiral benzylic building blocks (see scheme; TES=triethylsilyl). Taking advantage of the strongly electron-withdrawing nature of nitro groups, which can be conveniently transformed into other functionalities, this functionality was incorporated into aromatic systems as a temporary activating group. Copyright ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.