文献类型：期刊文献

英文题名：Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid

作者：Li, Yuanyuan[1];Yuan, Xing[1];Shen, Yunheng[1];Zhao, Jing[2];Yue, Rongcai[1];Liu, Fang[1];He, Weiwei[3];Wang, Rui[3];Shan, Lei[1];Zhang, Weidong[1,4]

机构：[1]Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China;[2]Logist Engn Univ, Dept Math, Chongqing 401311, Peoples R China;[3]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[4]Shanghai Inst Pharmaceut Ind, Shanghai 200040, Peoples R China

年份：2016

卷号：8

期号：3

起止页码：521

外文期刊名：AGING-US

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000375450300011)】；

基金：The work was supported by Professor of Chang Jiang Scholars Program, NSFC(81230090, 1302658), Shanghai Leading Academic Discipline Project (B906), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300), the Scientific Foundation of Shanghai China (12401900801, 13401900101), National Major Project of China (2011ZX09307-002-03) and the National Key Technology R&D Program of China (2012BAI29B06).

语种：英文

外文关键词：Bacopaside I; Alzheimer's disease; beta-amyloid; immune; phagocytosis; APP/PS1 mice

摘要：Standardized extracts of Bacopa monniera (BME) have been shown to exert a neuroprotective effect against mental diseases, such as depression, anxiety and Alzheimer's disease (AD), in chronic administration studies. However, its mechanism of action has remained unclear. In this study, we evaluated the therapeutic effect of Bacopaside I (BS-I), a major triterpenoid saponin of BME, on the cognitive impairment and neuropathology in APP/PS1 transgenic mice and explored the possible mechanism from a biological systems perspective. We found that BS-I treatment significantly ameliorated learning deficits, improved long-term spatial memory, and reduced plaque load in APP/PS1 mice. We constructed BS-I's therapeutic effect network by mapping the nodes onto the protein-protein interaction (PPI) network constructed according to their functional categories based on genomic and proteomic data. Because many of the top enrichment categories related to the processes of the immune system and phagocytosis were detected, we proposed that BS-I promotes amyloid clearance via the induction of a suitable degree of innate immune stimulation and phagocytosis. Our research may help to clarify the neuroprotective effect of BME and indicated that natural saponins target the immune system, which may offer new research avenues to discover novel treatments for AD.