文献类型：期刊文献

中文题名：Effect of the microbial lipopeptide on tumor cell lines: apoptosis induced by disturbing the fatty acid composition of cell membrane

作者：Xiangyang Liu[1,2];Xinyi Tao[1];Aihua Zou[1];Shizhong Yang[1];Lixin Zhang[2];Bozhong Mu[1]

机构：[1]State Key Laboratory of Bioreactor Engineering and Institute of Applied Chemistry,East China University of Science and Technology,Shanghai 200237,China;[2]Institute of Microbiology,Chinese Academy of Sciences,Beijing 100190,China

年份：2010

卷号：1

期号：6

起止页码：584

中文期刊名：Protein & Cell

外文期刊名：蛋白质与细胞（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2011_2012】；PubMed;

基金：This work was supported in part by grants from the National Natural Science Foundation of China(Nos.50574040,30700015);the Ministry of Science and Technology of China(2007CB707801);Shanghai Science and Technology Commission(No.071607014);China Postdoctoral Science Foundation(20080440545);the National Programs for High Technology Research and Development Program(863 Program)(No.2006AA09Z402);Key Project of International Cooperation(2007DFB31620).L.Z.is an awardee for Hundred Talents Program.

语种：英文

中文关键词：Bacillus subtilis;lipopeptide;antitumor activity;membrane fatty acid;apoptosis

摘要：Microbial lipopeptides play an important role in apoptosis induction of tumor cells.However,there is little knowledge about the relationship between apoptosis induction and membrane fatty acids.The present study focused on the effects of lipopeptides produced by Bacillus subtilis HSO121 on Bcap-37 cell lines.3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl(MTT)colorimetric assay and surface tension measurements,showed that the critical micelle concentration(CMC)was a critical level for the inhibitory activity of lipopeptides on the growth of Bcap-37 cells.Under the CMC,the order of least to greatest cytotoxicity effect on cancer cell lines by lipopeptides is C13-lipopeptide