文献类型：期刊文献

英文题名：Direct Transformation of Aryl 2-Pyridyl Esters to Secondary Benzylic Alcohols by Nickel Relay Catalysis

作者：Wu, Xianqing;Li, Xiaobin;Huang, Wenyi;Wang, Yun;Xu, Hui;Cai, Liangzhen;Qu, Jingping[1];Chen, Yifeng[1]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：21

期号：7

起止页码：2453

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000464247500111)，CCR-EXPANDED(收录号:WOS:000464247500111)】；

基金：We thank Prof. Timothy Newhouse (Yale University) and Prof. Zhangjie Shi (Fudan University) for insightful discussion. We thank Prof. Pei-Nian Liu (ECUST) for the use of the equipment. We thank Mr. Yangyang Weng (ECUST) and Mr. Chenglong Wang (ECUST) for protocol check. This work was supported by the Youth 1000-Talent Plan Program, East China University of Science and Technology for startup funding, NSFC/China (21421004, 21702060), Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX03) and the Program of Introducing Talents of Discipline to Universities (B16017), and the Fundamental Research Funds for the Central Universities (WJ1814012).

语种：英文

摘要：A direct transformation of aryl esters to secondary benzylic alcohols via tandem Ni-catalyzed cross-coupling reactions of aromatic 2-pyridyl esters with alkyl zinc reagents and carbonyl group reduction by Ni-H species is achieved. Preliminary mechanistic studies reveal that the Ni-H species is generated in situ via beta-hydride elimination of the Negishi reagents. The reaction is catalyzed by bench-stable nickel salts under mild conditions with wide functional group tolerance.