文献类型：期刊文献

英文题名：ortho-(Methyltosylaminoethynyl)benzyl glycosides as new glycosyl donors for latent-active glycosylation

作者：Chen, Xiaoping[1];Shen, Dacheng[1];Wang, Qiaoling[1];Yang, You[2];Yu, Biao[1]

机构：[1]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China

年份：2015

卷号：51

期号：73

起止页码：13957

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000360398900022)，CCR-EXPANDED(收录号:WOS:000360398900022)】；

基金：Financial support from the Ministry of Science and Technology of China (2012ZX09502-002), the National Natural Science Foundation of China (21432012), the Fundamental Research Funds for the Central Universities (WY1514052), and the Shanghai Pujiang Program (15PJ1401500) is gratefully acknowledged.

语种：英文

摘要：A new glycosylation protocol employing ortho-(methyltosylaminoethynyl)benzyl glycosides as glycosyl donors and TMSOTf as the catalyst is disclosed. These donors can be readily prepared from the corresponding 'latent' ortho-iodobenzyl glycosides via a Sonogashira coupling, thus providing a new approach for the 'latent-active' synthesis of glycans.