文献类型：期刊文献

英文题名：Triplex Au-Ag-C Core Shell Nanoparticles as a Novel Raman Label

作者：Shen, Aiguo[1];Chen, Lifang[2];Xie, Wei[1];Hu, Juncheng[3];Zeng, Ao[1];Richards, Ryan[4];Hu, Jiming[1]

机构：[1]Wuhan Univ, Coll Chem & Mol Sci, Minist Educ, Key Lab Analyt Chem Biol & Med, Wuhan 430072, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[3]S Cent Univ Nationalities, Coll Chem & Mat, Wuhan 430074, Peoples R China;[4]Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA

年份：2010

卷号：20

期号：6

起止页码：969

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20101412820252);WOS:【SCI-EXPANDED(收录号:WOS:000276267600015)】；

基金：Drs. A. Shen and L. Chen contributed equally to this work. This work was supported by National Natural Science Foundation of China (NSFC) (Nos. 20705025, 30772058, 20927003, 90913013). Supporting Information is available online from Wileylnterscience or from the authors.

语种：英文

外文关键词：Medical applications - Molecular imaging - Silver nanoparticles - Silver compounds - Carbon - Gold coatings - Shells (structures) - Raman spectroscopy - Benzoic acid - Biocompatibility

摘要：Monodispersed, readily-grafted, and biocompatible surface-enhanced Raman spectroscopic (SERS) tagging materials are developed; they are composed of bimetalic Au@Ag nanoparticle (NPs) for optical enhancement, a reporter moleculae for spectroscopic signature, and a carbon shell for protection and bioconjugation. A controllable and convenient hydrothermal synthentic route is presented to synthesize the layer-by-layer triplex Au-Ag-C core-shell NPs, which can incorporate the Raman-active label 4-mercapto benzoic acid (4-MBA). The obtained goled seed-silver coated principles can be coated further with a thickness-controlled carbon shell to form colloidal carbon-encapsulated Au-core/Ag-shell spheres with a monodisperse size distribution. Furthermore, these SERS-active spheres demonstrated interesting properties as a novel Raman tag for quantitative immunoassays. The results suggest such SERS tags can be used for multiplex and ultrasensitive detection of biomolecules as well as nontoxic, in vivo molecular imaging of animal or plant tissues.