文献类型：期刊文献

英文题名：Rational Design and Fabrication of Biomimetic Hierarchical Scaffolds With Bone-Matchable Strength for Bone Regeneration

作者：Lian, Ruixian[1]; Xie, Peng[1]; Xiao, Lan[2,3]; Iqbal, Zoya[1]; Zhang, Shihao[4]; Kohn, Joachim[5]; Qu, Xue[1]; Liu, Changsheng[1]; Li, Yulin[1]

机构：[1] The State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China; [2] Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia; [3] The Australia-China Centre for Tissue Engineering and Regenerative Medicine [ACCTERM], Brisbane, QLD, Australia; [4] New Organic Chemical Materials Hubei Collaborative Innovation Center, Key Laboratory of Organic Functional Molecular Synthesis and Application of Ministry of Education, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, China; [5] Department of Chemistry and Chemical Biology, New Jersey Center for Biomaterials, Piscataway, NJ, United States

年份：2020

卷号：7

外文期刊名：Frontiers in Materials

收录：EI(收录号：20210909983247)

语种：英文

外文关键词：Pore structure - Biomineralization - Bone - Biodegradable polymers - Fracture mechanics - Plastic coatings - Scaffolds - Biomimetics - Amino acids - Scaffolds (biology) - Sols

摘要：The development of scaffolds with bone-mimicking compositions, hierarchical structure, and bone-matchable mechanical properties may offer a novel route for the achievement of effective bone regeneration. Although bioactive glasses have been widely utilized for bone regeneration at the clinical level, their brittleness and uncontrolled pore structure limit further applications. Herein, this study aims to develop a kind of bioactive scaffold with a macroporous/microporous/mesoporous structure via impregnating a sponge template with mesoporous bioactive glass (MBG) sol, followed by sponge template removal. In order to improve the mechanical properties and stability of the MBG scaffolds, desaminotyrosyl ethyl tyrosine polycarbonates (PDTEC), a biodegradable polymer which does not induce acid side-effects caused by conventional polylactide, was selected to decorate the resulting hierarchical scaffolds through a surface coating approach. The PDTEC functionalization endowed the scaffolds with improved mechanical strength matching the bearable range of trabecular bone (2–12MPa). Meanwhile, the relative neutral pH value was maintained during their degradation process. In vitro studies demonstrated that the PDTEC accelerated the biomineralization of the scaffolds, and promoted the attachment and proliferation, holding high promise for bone regeneration. ? Copyright ? 2021 Lian, Xie, Xiao, Zhang, Kohn, Qu, Liu and Li.