文献类型：期刊文献

中文题名：反渗透法回收结晶母液中6-APA

英文题名：Recovery of 6 aminopenicillanic Acid from Crystallization Mother Liquor Using Reverse Osmosis

作者：曹学君[1,2,3];邬行彦[1,2,3];吴彤[1,2,3];金科铭[1,2,3];李明健[1,2,3];黄少坤[1,2,3];谭建德[1,2,3];董超丽[1,2,3]

机构：[1]华东理工大学生化工程系生物反应器工程国家重点实验室;[2]密理博中国有限公司;[3]珠海丽珠(集团)合成制药厂

年份：1998

卷号：14

期号：4

起止页码：468

中文期刊名：生物工程学报

外文期刊名：Chinese Journal of Biotechnology

收录：CSTPCD;;Scopus;北大核心:【北大核心1996】；CSCD:【CSCD2011_2012】；PubMed;

语种：中文

中文关键词：青霉素裂解液;6-APA;回收;反渗透法

外文关键词：Reverse osmosis, 6 APA, crystallization mother liquor concentration, crystallization

摘要：青霉素裂解液在结晶６ＡＰＡ后，仍残留有０３％（Ｗ／Ｖ）６ＡＰＡ，生产厂每天约有１５吨６ＡＰＡ结晶母液，若能将母液中残余产品进行回收，每天可多得４０ｋｇ以上６ＡＰＡ，价值约在１９２００元以上，每年可得额外产值５７６万元以上（按３００ｄ计）。其...
Crystallization mother liquor usually containing about 0.3% of 6 aminopenicillanic acid(6 APA), was processed by reverse osmosis system (RO). 6 APA rejection factor to Nanomax 50 membrane (Millipore Co.LTD.) was above 99%. The salts contained in the mother liquor such as NH 4Cl, KCl can permeate the membrane. Three batches of typical RO experiments were carried out. 6 APA solution were concentrated 20～30 times at a yield of over 98%. The concentrated 6 APA solution was then crystallized with a yield of 83.5%～85.6% and purity of 97%. Another eight batches were repeated and the results were similar.