文献类型：期刊文献

英文题名：Visible light-induced cascade annulation of sulfoxonium ylides with azides for the synthesis of 2-trifluoromethyl indoles

作者：Cui, Jia-Huan[1];Chen, Qian-Yu[1];Zhang, Jun[1];He, Yan[2];Li, Xingguang[1];Liu, Pei-Nian[1,3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Jishou Univ, Coll Chem & Chem Engn, Jishou 416000, Peoples R China;[3]China Pharmaceut Univ, Sch Pharm, State Key Lab Nat Med, Nanjing 210009, Peoples R China

年份：2025

卷号：61

期号：3

起止页码：488

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001370768700001)，CCR-EXPANDED(收录号:WOS:001370768700001)】；

基金：The authors are grateful to the National Natural Science Foundation of China (22201073, 21925201, and 22161160319) and the Fundamental Research Funds for the Central Universities. The authors thank the Research Center of Analysis and Test of East China University of Science and Technology for help with the characterization.

语种：英文

摘要：An efficient protocol was reported for the synthesis of 2-trifluoromethyl indoles through visible-light-promoted intermolecular cyclization of sulfoxonium ylides with azides, without the need for external photocatalysts, transition metals, or bases. The formation of 2-trifluoromethyl indoles involves an intriguing cascade process including azide rearrangement, intermolecular nucleophilic addition, and visible-light-promoted cyclization of a key intermediate. The protocol features high efficiency, mild conditions, excellent substrate compatibility and good regioselectivity. The practicality of this approach is demonstrated through scale-up reactions and further modifications of the synthesized indoles.