文献类型：期刊文献

中文题名：Lithocarpins E-G, Potent Anti-Tumor Tenellone-Macrolides from the Deep-Sea Fungus Phomopsis lithocarpus FS508

作者：Jianlin Xu[1,2,3];Yuchan Chen[1];Zhaoming Liu[1];Saini Li[1];Yong Wang[3];Yuhong Ren[2];Hongxin Liu[1];Weimin Zhang[1]

机构：[1]State Key Laboratory of Applied Microbiology Southern China,Guangdong Provincial Key Laboratory of Microbiol Culture Collection and Application,Guangdong Open Laboratory of Applied Microbiology,Guangdong Institute of Microbiology,Guangdong Academy of Sciences,Guangzhou,Guangdong 510070,China;[2]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China;[3]Key Laboratory of Synthetic Biology,CAS Center for Excellence in Molecular Plant Sciences,Institute of Plant Physiology and Ecology,Chinese Academy of Sciences,Shanghai 200032,China

年份：2021

卷号：39

期号：5

起止页码：1104

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；

基金：Guangdong Provincial Special Fund for Marine Economic Development Project([2020]042);the National Natural Science Foundation of China(41906106);the Guangdong Special Support Program(2019TQ05Y375);Team Project of the Natural Science Foundation of Guangdong Province(2016A030312014);the GDAS_Project of Science and Technology Development(2019GDASYL-0103007);We sincerely thank Mr.Can Li of central laboratory of Southern Medical University for NMR measurements.

语种：英文

中文关键词：Phomopsis lithocarpus FS508;Polyketides;Structure elucidation;Antitumor agents;Apoptosis

摘要：Lithocarpins E-G,featuring a rare naturally-occurring highly oxygenated tenellone-macrolide skeleton,were isolated from the culture extract of a marine-derived fungus Phomopsis lithocarpus FS508.Their structures were fully elucidated by NMR and MS spectroscopic analyses and electronic circular dichroism calculations.Compounds 1-3 were evaluated for their in vitro cytotoxicities against HepG2,MCF-7,SF-268,as well as A549 cell lines,among which,compound 1 exhibited inhibitory activity against HepG2 cells with an IC_(50) value of 6.3 μmol/L.The further mechanistic investigation demonstrated that lithocarpin E could cause the apoptosis of HepG2 cells through activation of p-ERK,Bax,and caspase-3 gene expressions.