文献类型：期刊文献

英文题名：Synthesis and solution properties of pH responsive methoxy poly(ethylene glycol)-b-poly(γ-amino-ε-caprolactone)

作者：Liu, Jianjing[1];Zhang, Yan[1];Yan, Jinliang[1];Lang, Meidong[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China

年份：2011

卷号：21

期号：18

起止页码：6677

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000289692500036)】；

基金：Financial support from the National Natural Science Foundation of China (20804015), the Fundamental Research Funds for the Central Universities (WD0913008, WD1014036), Specialized Research Fund for the Doctoral Program of Higher Education (200802511021), Shanghai Key Laboratory Project (08DZ2230500) and Program for Changjiang Scholars and Innovative Research Team in University (IRT0825) are gratefully acknowledged.

语种：英文

摘要：A series of water-soluble and cationic methoxy poly(ethylene glycol)-b-poly(gamma-amino-epsilon-caprolactone) (mPEG-b-PACL) has been synthesized via ring opening polymerization of gamma-(carbamic acid benzyl ester)-epsilon-caprolactone (gamma CAB epsilon CL) using mPEG as a macroinitiator and Sn(Oct)(2) as a catalyst, and subsequent hydrolysis of the Cbz protecting groups under acidic conditions. The well-defined structure of copolymers was confirmed by H-1 NMR and FTIR spectra. In addition, size exclusion chromatography (SEC) results indicated that the copolymer had a symmetric peak and a relatively narrow polydispersivity. The thermal properties were influenced by hydrogen bonding originating from the amino groups on the backbone based on differential scanning calorimetry (DSC) results. Furthermore, the solution properties have been investigated in water by a zetamasters instrument and dynamic light scattering (DLS). The results demonstrated that the aggregates exhibited a rich pH-responsive behavior with an appropriate PACL length. Successful formation of aggregates with spherical morphology was demonstrated beyond a critical PACL length by transmission electron microscopy (TEM). The mPEG-b-PACL block copolymer did not have any significant cytotoxicity against human dermal fibroblasts up to 500 mu g mL(-1). Moreover, it has improved cell proliferation behavior according to MTT assays. Based on all these notable advantages, mPEG-b-PACL copolymer would be a potential candidate for biomedical and pharmaceutical applications.